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Human Clones, Stem Cells & Public Accountability

Prof. Geoffrey Hunt

University of Surrey, UK 

Also published as: Hunt, G. ‘Clones, Stem Cells & Human Survival: The Ethical Question’, [Trans. into Japanese by Chikako Noma], Journal of Seizon and Life Sciences [ISSN 0917-0138] Vol. 13, series A, Sept. 2002, pp. 56-74.


“We can distinguish cleverness about means from wisdom about ends, and we are loath to entrust the future of the race to those who cannot tell the difference.” Leon R. Kass1

 1) Introduction

Great controversy has been aroused by the claim that it is now possible to clone human beings; to produce almost exact copies of a desired human individual. Cloning takes place without the union of egg and sperm, and indeed men are not necessary. (Only a few women are needed.) The first experiments to do so are scheduled to begin this month. This real possibility struck the world when in 1997 it was announced at a UK research institute that they had produced ‘Dolly’ the sheep, who was a clone of her mother. Dolly has no father. This announcement comes into a world already trying to absorb the implications of genetic engineering, genetically modified food, transgenic tissue transplants, foetal tissue transplants, in vitro fertilisation, stem cell research, the mapping of the human genome and many other developments. It seems that it is not enough that we face an uncertain future due to unwitting human damage to the environment such as deforestation, global warming and climate change, a growing hole in the ozone layer, polluted seas and air, desertification, the utilitarian despoiling of our beautiful forested mountains with highways and transmission masts, and new epidemics such as HIV-AIDS and BSE-CJD. It seems we are also deliberately bent on greatly increasing our chances of global self-destruction. Can the human race survive? At present, it seems unlikely. It is unlikely because our technical cleverness is not matched by any ethical wisdom. Because we can do something, it does not follow that we ought to do it.

 

2) What is a clone?

A Clone is a population of genetically (almost) identical organisms or cells. The word ‘clone’ is also used for one individual in such a population. Clones are nothing new, for they arise in nature. Any organism that reproduces asexually, by dividing itself rather than combining with another organism, is a clone. Many simple plants and animals, such as algae, plankton and amoeba, are clones. Shocked as we are by the thought of a human clone we forget that nature already produces human clones: naturally occurring identical (monozygotic) twins and triplets are clones. Such twins and triplets originate from the splitting of embryonic cells so have exactly the same genetic programme.

    For centuries human beings have practiced the cloning of plants, such as vegetables, flowers and fruits.

    Dolly2 was not the first laboratory clone. Successful cloning by nuclear transfer (see below) with frog cells was announced in 1975, and in 1989 details of the first piglet clone after nuclear transfer were published.  What was new about Dolly was that she was produced not from an embryonic cell, but from a (somatic) cell from the mammary gland of her mother. Scientists have already cloned a number of animals, including mice and cows3.

3) How is it done?

How are animal clones produced in the laboratory? A small sample of cells is taken from the ‘parent’ individual and is then grown as a culture. When the cells have multiplied they are treated ‘to turn back their biological clock’. This returns them to an undifferentiated state. How this happens is not understood. They now have the potential to grown into any type of cell. This potential is not understood. The genetic material (the nucleus) is taken from one of these cells. Also, an unfertilised egg cell is taken from woman/female, and the nucleus removed (it is then an ‘enucleated cell’.)

The nucleus (with its genetic material) from a cultured cell is injected into an enucleated egg. A tiny electric jolt fuses the egg and the genetic material, making new nucleus. How this happens is not understood. The new cell then multiplies. How it multiplies is not fully understood. In these cells (of mammals), the outer layer is for the placenta and inner layer is stem cells. Stem cells can become any of 300 types of cells in human body. What makes this possible is not understood.

There are now two possibilities. 1) Therapeutic cloning: cloned stem cells may possibly be used to repair or replace defective tissues and organs – possibly by injecting the stem cells into a specific area. This research is still at an early stage, and for the most part scientists do not understand why they get the results that they do or what the dangers are. 2) Reproductive cloning: a complete embryo is allowed to develop and then implanted in the womb of a surrogate (genetically unrelated) mother, and development takes place as usual. This has been achieved with non-human animals, but with a very low success rate, and many abortions and deformities.

            It is also possible genetically to engineer the material in the nucleus, altering the original genetic programme to get a clone with a ‘useful’ modification (such as high milk-yield cows), before it is introduced into the enucleated egg cell. The possibilities are enormous, and so are the dangers.

 

 

4) Ethical Disagreement

There are many different kinds of ethical disagreement about all this. Some are more radical than others. Some people think that all research involving human embryos is wrong. They say that embryos are potential people and should be respected. This would mean that all human genetic engineering, and stem cell research, as well as human cloning, would be wrong.

Some people say it is alright to use human embryos in research as long as they are not specially cultured for research purposes, but are only ‘spare’ embryos (from invitro fertilization) that would otherwise have been destroyed. There is disagreement within this group of people as to whether such ‘spare’ embryos could be used for cloning or not.

Some people say that cell-cloning in order to develop stem cells for therapeutic purposes is alright, but cloning whole human beings is wrong. This is the position that most scientists seem to take at present. Some people take the view that while cloning humans is wrong, cloning whole animals such as cows, tigers or monkeys is alright, while others think all animal cloning is wrong, even if stem cell cloning is alright.

The radical view that all embryonic research is wrong is taken by the Catholic Church. Pope John Paul II personally lobbied Bush to oppose federal funding for such research when they met at the Vatican this year. The Pope said:  “A free and virtuous society, which America aspires to be, must reject practices that devalue and violate human life at any stage from conception to natural death.” He added that consumerism turns “human reproduction into a manufacturing process in which children are made in laboratories to preordained specifications and, potentially, in multiple copies”.

The opposite radical view is taken by a group of well-known scientists and ‘free thinkers’. In a ‘Declaration in Defence of Cloning’ they have said:

 

“But we believe that there is a very real danger that research with enormous potential benefits may be suppressed solely because it conflicts with some people's religious beliefs. It is important to recognize that similar religious objections were once raised against autopsies, anaesthesia, artificial insemination, and the entire genetic revolution of our day - yet enormous benefits have accrued from each of these developments … We see no inherent ethical dilemmas in cloning non-human higher animals. Nor is it clear to us that future developments in cloning human tissues or even cloning human beings will create moral predicaments beyond the capacity of human reason to resolve.” 4

 

Ideally, every human being should think about what their position is on this issue, and not be intellectually bullied by scientists, bioethicists, politicians and others who claim to have more moral sense than ordinary people.

 

5) Why Therapeutic Cloning in Humans?

There seem to be two main motives for therapy in humans by means of cloned stem cells. One is that it may prevent a great deal of suffering. The other is that it may make a great deal of money. While it will certainly make a lot of money for a few people, will it prevent a lot of suffering? I discuss this question later. It is said that therapeutic cloning can be used to replace disease genes such as those of cystic fibrosis, Duchenne muscular dystrophy, polycystic kidney disease, Huntington’s chorea, or genes that predispose to certain disease conditions such as cancer, schizophrenia, coronary heart disease or diabetes. Some people envision a ‘library’ of good working copies of genes, or enhanced ones, which may always be available (at a price) for cloning therapy.

Some people are already speaking not so much of preventing suffering but what cloning techniques (wrongly called ‘therapies’) might do for tissue or organ enhancement. If you do not like some part of your body, perhaps it will be possible to remove it and replace it by stem cell regeneration with a shape or colour you prefer. Cosmetic surgery would become a thing of the past. People might also consider enhancing the tissue of their brain or muscles in order to perform better. You would just need the money to pay for it.

6) Why reproductive Cloning?

Why would anyone want to have a cloned human being? The only medical or semi-medical reason that has been given is as a form of infertility treatment by: producing a genetically related child of a completely infertile man or woman (from a somatic cell). Other non-medical reason that have been given by some people are: to replace a cherished child or other person who has died; to produce a copy of a person considered especially important to humanity (e.g. a genius); to produce enhanced beings (eugenics). We need to think about whether any of these are good reasons, even if the reproductive cloning technology is possible and safe. High profits may motivate some doctors, scientists and companies to embark on reproductive cloning regardless of whether the reasons are good or not.

If human cloning is allowed how long will it be before its main aim is human enhancement i.e. eugenics? Would you like your child to be like a famous scientist or poet? Well, why not buy the cloning treatment for your wife, girlfriend or pay for a surrogate mother? Or, would you like to have your own personal copy of a famous pop star or film actor, why not buy one? Why not keep a travelling copy of your boyfriend or girlfriend, so that you will not miss them when you travel away? Is this really the way we should think?

 While international agreements and national laws have banned human reproductive cloning, some scientists are still prepared to go ahead with it. An Italian gynaecologist, Severino Antinori5, announced in August this year that he and his team would secretly begin human cloning experiments in November. He says he will help infertile men by impregnating about 200 women with cloned embryos even if he loses his medical registration. (Other doctors are already expelling him from professional associations.) The nucleus of an infertile man’s somatic cell will be injected into an enucleated egg, possibly taken from the man's wife or partner.

In September this year it was reported that Mark and Tracy Hunt (See photo next page) spent up to £350,000 trying to clone their 10-month-old son who died after a heart operation two years ago. They used legal compensation to pay an American scientist, to carry out the procedure. The scientist is a member of the Raelians, a sect which claims humans were cloned by aliens. They stopped the funding when the scientist got carried away with making publicity for the Raelians. They still have their child’s tissue samples and hope to clone him in the future.

7) Some misconceptions

Before we consider some arguments in detail we should note that many popular discussions about human cloning are at a low level. Scientists have failed to make themselves clear to the public and have left the news media to misrepresent many important facts.

To begin with there is often a simple confusion between cloning of cells and cloning of whole organisms, including humans. Then it is common for people to think that the clone of organism X will be absolutely identical to X in every respect. However, this is not true. Natural identical twins are probably more alike one another than a cloned human would be to its ‘parent’.  Even identical twins are not really identical and may become very different as they grow older. In any case they are separate people with separate lives. Here are the main reasons for the non-identity of clone and parent:

(a) The cloned cell makes use of mitochondrial material in the enucleated egg, and this is why monovular twins are genetically closer than are artificially produced clones. Dolly is not an identical clone of its parent.

(b) There will be some genetic mutation during development, however small.

(c) The physical environment has an impact from gestation through adult life (including biochemical ambience, nutrition, disease, and accident).

(d) Upbringing and culture have an impact (including language, social norms and education).

People who say that the very existence of a human clone is morally unacceptable often forget that in most modern societies there is nothing morally reprehensible about the existence of identical twins or triplets. People who emphasise the genetic similarity of clone and parent as being in itself the main reason for rejecting cloning forget that human beings already share over 98% of their genetic material with chimpanzees. We do not find chimpanzees, or humans, reprehensible for this reason.

Some people seem to think that if cloning were allowed, then at some time in the future everyone would be exactly the same. They forget that, besides the fact that clones are not really identical, clones would presumably not be from one individual but many genetically different individuals.

People are often disturbed by the idea of cloning because they think that if A1 is a clone of A then you have two copies of the same “person”. This is the most important misconception, because it leads to the most common objections and support for human cloning. In fact, you really only have here two people who are biologically very close, but they are still two different people, with their own lives to live and are equally deserving of human respect.

My view is that an immediate ten-year moratorium should be put on all biotechnology involving animal and human somatic cell nuclear transfer. This would halt both stem cell research and, more specifically, human cloning. I now give my reasons.

 

8) Human Therapeutic cloning: The Debate

i) Therapy

It is not unreasonable to speculate that therapeutic cloning might have benefits for many people with a wide range of dysfunction and disability.

Hughes, a bio-ethicist, has written in defence of a wide range of genetic technologies, including cloning of embryos. He says,

 

 In the case of genetic engineering my broad assertion is that gene-technologies can, and probably will, give people longer, healthier lives, with more choices and greater happiness. In fact, these technologies offer the possibility that we will be able to experience utilities greater and more intense than those on our current mental pallet. Genetic technology will bring advances in pharmaceuticals and the therapeutic treatment of disease, ameliorating many illnesses and         forms of suffering.”6

 

There are two main counter-arguments. Firstly, the overwhelming majority of human disease and disability is not caused by genetic defects. One only has to think of the mortality and suffering caused on a planetary scale by malaria, TB and gastrointestinal infection. Even if we restrict ourselves to disability we find that the great majority of cases are due to birth trauma, environmental damage and accident. Secondly, even if we use cloning/stem cell technologies to engineer solutions to some public health problems this raises the question of why we should take the risk of unforeseen genetic ecological damage when we already know what the public health solutions are (such as, for example, clean water). In the public health realm most of the obstacles are political, social and economic not technological.

 

ii) Unlimited Human Enhancement

As though Hughes does not find his own therapeutic argument very convincing he also proposes that such cell engineering technologies could enhance the characteristics of the human race. He says,

 

“Somewhat further in the future, our sense organs themselves may be re-engineered to allow us to perceive greater ranges of light and sound, our bodies re-engineered to permit us to engage in more strenuous activities, and our minds re-engineered to permit us to think more profound and intense thoughts. If utility is an ethical goal, direct control of our body and mind, through genetic control, cybernetics, prosthetics, or whatever, suggests the possibility of unlimited utility, and thus an immeasurable good.”

 

When he says “us” who does he mean? Given current political-economic arrangements it seems that such benefits, if they are benefits, would only be available to those who could pay for them. I fear that “re-engineered minds” may not only be a eugenic programme, but one in which cleverness and self-interest is once again being confused with wisdom and compassion.

iii) Ecological Implosion?

Medicine has always faced great uncertainties in its diagnoses, prognoses and treatments. It has also had a great problem admitting to this uncertainty, for to do so would undermine its own ideological power7. If scientists could only be truthful about the great areas of ignorance and uncertainty involved in cell engineering then I think the public would call for an immediate halt. Clearly the public is already justifiably alarmed by genetically modified food, and yet genetically modified humans are on the horizon8.

If we look again at my diagrams of the cloning techniques we find that there are dozens of unanswered fundamental questions at each stage. To take one example, we have a very poor understanding of the interaction between the nucleus and the cytoplasm and its mitochondria, and yet nuclear transfer cloning depends on separating them. Is it not cause for alarm that the vast majority of organisms produced during cloning experiments are aborted, dysfunctional or deformed? Once we have cultured stem cells ready for therapeutic transplant we then have to face our ignorance about histocompatibility antigens encoded by mitochondrial DNA.

While trial and error is a research strategy that may be fairly harmless in certain areas, mechanics for example, it is surely a very dangerous experimental approach in manipulating the life process itself. When one considers that someone as eminent as the UK’s Professor Robert Winston, who pioneered In Vitro Fertilisation techniques, can blandly suggest that “Cloning techniques might also be useful in developing transgenic animals – for example, for human xenotransplantation”9, then we must consider the possibility that we are already playing with fire. Further genetic engineering experiments may eventually, through out-of-control and hidden permutations, lead to an ecological implosion at the very roots of life’s process. One cannot say that it is impossible, and even its likelihood cannot be rationally assessed.

 

iv) Exploitative approach to humans

Scientists and bioethicists who speak with such optimism about new cell technologies do not take into account the widespread iatrogenic disease and psychological dependency already brought into the world by conventional medicine. The fact that modern medicine has not dealt adequately with public health conditions, ranging from malaria to HIV-AIDS, should in itself act as a warning that political and social maturity are a precondition for further human advancement. Everywhere we see modern medicine already taking advantage of the wealthy sick, ignoring the poor sick, and killing and hurting millions in its misdirected profit-driven endeavours. In the UK alone about 5,000 people are killed by hospital infections every year, about twice as many are killed by medical error and negligence, while hundreds of thousands are dependent on sleeping pills and anti-depressants.

Medicine’s great potential for human welfare is still thwarted by humanity’s failure to transcend its ignorance, greed and pride. Why should we now expect any better from scientists and doctors in the pay of biotechnology companies?

Given what we know about humanity’s contemporary ethical level does it come as a surprise that some are looking forward to the possibility of creating banks of cloned human embryos, and cells and tissues derived from them, as a resource for people who can pay for bodily enhancement? We are only a step away from manipulating the core human life process itself as a further means of man exploiting man.

9) Human Reproductive cloning: The Debate

i) Animal cloning

It is helpful perhaps to think about the implications of reproductive cloning with animals before we consider the question of cloning humans. My view is that embryonic cell cloning of animals may be justifiable, whereas all nuclear transfer cloning should be put under a moratorium. The former may be justifiable for two reasons. Firstly, to save animals (such as the tiger and panda) which are on the brink of extinction. This seems to me to be a good reason. Secondly, there may be a human welfare reason for producing livestock (animal husbandry) in this way. I am not so sure that the reasons would be good ones, but this is not the place to explore this further. Suffice it to say that embryonic cloning of an animal for its wool for example seems, on the face of it, to be harmless enough, whereas such cloning of cows and sheep for eating is ethically suspect. One problem with cloned animal populations to be kept in mind is the commonality of their disease susceptibilities. Anyway, the livestock biotechnology’s real interest is in the big profits of nuclear transfer cloning (not cloning by embryonic separation).10

 

ii) Abnormality and Ecology

For every 100 cloning attempts fewer than five result in live births. Of the live births a large proportion are abnormal, some of them grossly abnormal.11 In the case of Dolly it required 277 nuclear transfers to produce the one viable clone. I have already discussed unacknowledged scientific uncertainties and the dangers of ecological implosion (See 8iii) above). Regarding human reproductive cloning its is undoubtedly highly irresponsible to accept the very high probability of abortion and abnormality. It is hard to see what benefits could possibly outweigh these dangers (see infertility treatment below).

Most often scientists do not even understand the scientific basis of each abnormality, they just throw it away. Abnormalities are seen as a frustrating waste of time and money. This is not only unscientific, it is irresponsible because no real effort is being applied even to acknowledge the gross and unexpected consequences of the biotechnologist’s actions let alone understand their basis and implications for ecology and humanity. Human reproductive cloning faces a number of ethical objections, but it surely suffices that the potential for the suffering both of the ‘parents’ and the resultant offspring is much too great to outweigh any benefits. The first human clone may seem alright at first, and have serious mental or physical problems later. How will the ‘parents’ feel then? There are alternatives that do not carry such awful risks. The potential financial rewards and fame of the clone doctors are irrelevant to the rightness of such a course of action.

I now look at reasons why someone might think it desirable to replace a person with a ‘copy’. I think they are all very bad, even absurd, reasons.

 

iii) Grief therapy?

Someone might want to replace someone who has died or is about to die, because this grieves them. I mentioned the case of Mr and Mrs Hunt and their wish to clone their dead child Andrew (See 6) above). Mr Hunt is reported as saying: “When you let go, you turn your back on your child, given the fact that there’s an option that you don’t have to”. Mrs Hunt has said: “We have another baby, and he’s lovely, and we love him dearly, and he’s dear and precious to us. But he is not Andrew. I could have ten kids. They would all be different. They’re not that little boy.” What the Hunts do not understand is that the cloned child would also be “different” and would not be Andrew. Therefore cloning would be an enormous disappointment to them, even if it succeeded, and even if we put aside all other objections. You cannot clone a person, you can only clone a human organism. The Hunts are not thinking about what their motives and actions would mean for a person brought into the world in this way. This person would not be valued for who they are, but because they are thought to be someone else.

This is, perhaps, an understandable response of grieving parents, but is it wise? Is this not a situation in which anyone with concern for such a grieving parents would wish to help them think through and make adjustments to the limits of human life. Science cannot and will never eradicate grief; only human compassion and wisdom can ameliorate it in the process of learning from the experience itself.

 

iv) Special person?

Some popular writers have spoken of the possibility of cloning people who are special to some individual or to humanity. I could have my own copy of a film star, or the human race might like to have a copy of someone like Einstein. This is absurd. As I have said, such clones would be separate people in their own right, even if they shared characteristics with the ‘parent’; and they may well resent being treated as ‘copies’ and do the very opposite to what is expected of them. Our Einstein clone might decide to behave like a complete idiot.

 

v) ‘Genetically useful’ clones?

In some popular writings we also find the suggestion that humans with genetically useful traits might be cloned. In fact this is not so unreal as it might at first appear. Already a number of couples are having what the media have called ‘designer babies’.12 These are not clones but are selected by IVF and genetic screening so that they have biological qualities that are useful in saving the life of a sibling. We can see how this idea could be extended to the production of ‘useful’ clones; this is surely abhorrent. It is a manipulative approach to making babies. As a cloned individual I would have to live with the fact that my sole reason for existing was to provide for someone else’s existence. ‘Designer babies’ might come to feel the same way, even though they are not clones.

            Very much the same considerations apply to the idea of cloning special group characteristics and other eugenic fantasies. For example, one might envisage cloning a group of individuals who could better withstand the long journey to Mars and other space travel. And what if they do not want to go to Mars!

 

vi) Self-Cloning?

There are wealthy people in the USA who try to dodge death by means of cryogenics. This involves freezing their heads in liquid nitrogen when they die, in the hope that when technology has advanced they will be restored to life by means of a body transplant. It does not seem to occur to them that if this bizarre experiment succeeds (which is highly unlikely) it is almost certain that they would not remember anything of their previous life, and would therefore be a completely new person who would have to begin life as an adult, probably disabled, and with the mind of a newborn baby. Sooner or later they would have to face death again. Cloning holds out a similar bizarre prospect: I could clone myself. The trouble is that the clone would not be my self at all. It might even hate me! Therefore such cloning has no purpose. The idea is simply another symptom of a perversely individualistic, materialistic and consumerist society.

 

vii) Infertility Treatment?

Winston has said, “In human reproduction, cloning techniques could offer prospects to sufferers from intractable infertility. At present there is no treatment, for example, for those men who exhibit total germ cell failure.”9 Of all the arguments offered to justify human reproductive cloning this is undoubtedly the strongest. But it is not strong enough, in my view. To begin with, is cloning a treatment for infertility? No, it is not. The infertile man is not being treated at all. Since his dysfunction is not being corrected or even ameliorated cloning cannot be described as a ‘therapy’. We would simply be using cloning to circumvent the infertility. It would be a substitute for sexual reproduction because we would be using a cell from the infertile man’s body as a substitute for a sperm cell.

My arguments about the risks of harm would apply here too, and they are the ones I would rely on. After all, there are safe alternatives such as adoption and artificial insemination by a donor (AID).

What gives me additional concern is that the discussions in this area do not include concerns about the children who may be produced in this way. Besides the risks of abnormality there is the question of how such a child would feel about their identity. We cannot say for sure how they will feel, but it could be problematic. They might feel that they do not have a ‘real’ mother because, biologically speaking, they are ‘completely’ like their father. A child cloned from a woman’s somatic cell (perhaps for a Lesbian couple) would have no biological father at all. They might feel that instead they have two ‘mothers’: the somatic cell donor and the surrogate gestational mother who probably provided the enucleated egg. A cloned child might grow to feel that they are not a genuine member of the (or a) family.

 

10) Conclusion

Recommendation

I have already recommended that an immediate twelve-year moratorium should be put on all biotechnology involving animal and human somatic cell nuclear transfer. This would halt both stem cell research and, more specifically, human cloning. In this period an in-depth international, multi-stakeholder and broad-based dialogue involving the public should take place. In the first two years the means by which such a dialogue should take place should be created under the auspices of the United Nations and World Health organisation. Accountability is even more important than technique – let’s solve the accountability problem first.13

During this period some individual doctors and scientists may attempt to proceed without international approval. I suggest that somatic cell nuclear transfer of animal cells should be made internationally illegal, and that national governments should be encouraged to enforce this. The transfer of human cell nuclei, including human transgenic experiments, should be made a ‘crime against humanity’ under international legislation, such a law (and related laws) to be reviewed at the end of the twelve year moratorium.


 

Notes

1   Kass, Leon R., ‘Preventing a Brave New World’, The New Republic (USA), May 2001.

2   Dolly was cloned at the Roslin Institute research centre in Edinburgh, Scotland, UK. See Campbell KHS, McWhir J, Ritchie WA, Wilmut I. ‘Sheep cloned by nuclear transfer from a cultured cell line’, Nature 1996; 380:64-6.

3    The Missyplicity Project, in the USA, is working on cloning a dog.

4   Declaration in Defence of Cloning and the Integrity of Scientific Research, Free Inquiry magazine, Volume 17, Number 3.

5   This is the Italian gynaecologist who made history in 1996 by helping a 62-year woman to have her own child.

6   Hughes, J. ‘Embracing Change with All Four Arms: A Post-Humanist Defence of Genetic Engineering’, Eubios Journal of Asian and International Bioethics, June 1996, 6(4):94-101(and translated into German in Telepolis). 

7   See: Katz, I. ‘Why Doctors don’t disclose uncertainty’, Hastings Centre Report, 1984, 14:35-44; A I Moskowitz, B J Kuipers & J P Kassirer, ‘Dealing with Uncertainty, Risks and Trade-offs in Clinical Decisions’, Annals of Internal Medicine, 1988, 108:435-449; I P Kassirer, ‘Sounding Board Our stubborn quest for diagnostic certainty a case of excessive testing’, New England J. of Medicine, 1989, 320:1489-1491; M M Rosenthal, The Incompetent Doctor: Behind Closed Doors, Open University Press, 1995.

8   To give an example of concerns about GM food: the Monsanto corporation is apparently trying to monopolise soya, one of the world’s most important food crops. It has applied for a patent (No. WO 00/18963 Geneva) to a genetic sequence which would give it an exclusive right on high yield soy plants, seeds and seedlings. See: <http://www.greenpeace.org>.

9  Winston, Robert. ‘Editorial: The promise of cloning for human medicine. Not a moral threat but an exciting challenge’, Brit.Med.J. 1997; 314:913 (29 March).

10 For example, Wilmut’s work at the Roslin Institute, UK is sponsored by a biotechnology company, PPL Therapeutics, that plans to use the patented cloning technique to produce animals that will secrete valuable drugs in their milk. One report says: “American cloning companies are busy making multiple copies of just             about every top pedigree cow and bull in the land. In time, they hope identikit supercows and superbulls will be bred, milked and even butchered for profit, just like the old ones.” Cohen, P., Concar, D. ‘The awful truth’, New Scientist, 19 May 2001.

11  Abnormalities are reported, for example, in Campbell KHS, McWhir J, Ritchie WA, Wilmut I. ‘Sheep cloned by nuclear transfer from a cultured cell line’, Nature 1996;380:64-6. See also Cohen and Concar, op. cit., in note 10.

12  UK couple, Susanna and David Peters, went to the USA for (non-cloning) procedures to give birth to a baby with an immune system matching to their son, who is recovering from leukaemia and may relapse. The Guardian (London), October 15, 2001.

13  For the accountability of science and technology see Freedom to Care. This is a voluntary organisation, which I founded in 1991, that promotes the public accountability of large organisations in all sectors and supports professionals who speak up in the public interest. Information at: http://www.freedomtocare.org


Freedom to Care, 18th January 2004